After Lululemon see-through pants fiasco, exec departs

The Associated Press ? ? ? 11 hrs.

Lululemon said Wednesday that its chief product officer is stepping down, as it updated the production problems it has had with see-through pants.

The Canadian yoga wear maker said Sheree Waterson will leave effective April 15.

In a statement, the company said the departure was part of a plan to reorganize its product team to support long-term growth. It wouldn't comment specifically if the departure was related to the pants problem.

"As the organization matures organizational structure changes are often required," the company said in an email response to a query.

Lululemon late last month pulled its Luon pants from store shelves because the fabric was too sheer. On Wednesday the company said after evaluating its production issues, it found the problem stemmed from incomplete testing protocols combined with a style change in the pants pattern. Lululemon hired a new team, including senior level positions in quality, raw materials, and production, to look into the problem and oversee production of the Luon pants, which cost $72 to $98.

Related: Have you been hit hard by a career mistake?

Luon pants, made from a combination of nylon and Lycra fibers, are one of the retailer's product staples and account for about 17 percent of all women's pants in its stores. The company is offering customers full refunds or exchanges Lululemon did not say when it expects Luon pants to be back on shelves.

CEO Christine Day said the company stands by the outlook it offered on March 21 during an earnings report that came after the pants problem arose.

At that time, the company said withdrawing Luons will cut its revenue by $12 million to $17 million in the first quarter and by $45 million to $50 million for the rest of the year, particularly in the second quarter. It also said it expects first-quarter earnings of 28 to 30 cents per share. It reported earnings of 32 cents per share a year ago. The company expects the recall will pull its earnings down by 11 to 12 cents per share.

Analysts expect earnings of 29 cents per share on revenue of $339.7 million, according to FactSet.

? 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.

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SFO Serves Cease-And-Desist Letters To Keep Ride-Sharing Companies From Operating At The Airport

Last week, InstantCab announced to the world that it had received a partial cease-and-desist letter from the San Francisco International Airport, asking it to stop picking up and dropping off passengers there. Well, apparently it wasn’t alone, as other new transportation startups had also received the same notice last month. SideCar, for instance, confirmed that it received a cease-and-desist letter in early March. Zimride’s Lyft hasn’t responded to our inquiries, but we’ve heard that it too was one of the companies hit with a C&D notice. InstantCab, which operates a hybrid service with both community and taxi drivers, was actually the last of the companies to be served with a notice by SFO. And that notice applied to its community drivers only, not the taxi e-hail side of its business. The letters served to remind companies like Lyft and SideCar that the site is operated by the City and County of San Francisco and the Airport Commission, and also as a reminder that they didn’t have permits to operate on SFO premises. Without a permit, the notices say that continued operation of community driver services at SFO will be considered “an unlawful trespass.” In particular, the notice says those services are violating a couple of airport rules and regulations, including this one: Rule 3.3(E): No person shall enter or remain on Airport property and buy, sell, peddle or offer for sale or purchase any goods, merchandise, property or services of any kind whatsoever, on or from Airport property, without the express written consent of the Director or the Director?s duly authorized representative. Like every other airport in the world, SFO allows regulated taxi services to pick up and drop off passengers on the premises. Black car and limo services have been driving passengers to and from SFO for decades. And over the past few years, Uber has even provided a transportation alternative to those flying in and out of the airport — although Uber drivers are mostly indistinguishable from limo services, in part because the company partners with them for its UberBLACK and UberSUV service. The key distinguishing feature of the services hit by cease-and-desist letters by SFO seems to be that they employ community drivers who are not licensed by the San Francisco Municipal Transportation Agency or the California Public Utilities Commission. In that respect, SFO isn’t the first to try to outlaw these services. Lyft and SideCar (along

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Cancer checkpoint: Mitochondrial metabolic regulator SIRT4 guards against DNA damage

Apr. 4, 2013 ? Healthy cells don't just happen. As they grow and divide, they need checks and balances to ensure they function properly while adapting to changing conditions around them.

Researchers studying a set of proteins that regulate physiology, caloric restriction and aging have discovered another important role that one of them plays. SIRT4, one of seven sirtuin proteins, is known for controlling fuel usage from its post in the mitochondria, the cell's energy source. It responds to stressful changes in the availability of nutrients for the cell.

New research reveals that SIRT4 is also extremely sensitive to a different form of stress: DNA damage. This unsuspected response by the metabolic checkpoint means SIRT4 doubles as a sentry guarding against cancer, which is spurred by genetic abnormalities.

Sirtuins have become familiar for their connection to longevity and to resveratrol, the red-wine compound that activates SIRT1, but less attention has been focused on SIRT3, SIRT 4 and SIRT5, all of which are found in mitochondria. Marcia Haigis, HMS associate professor of cell biology, led a team that has uncovered SIRT4 as an important player in the DNA damage response pathway, coordinating a sequence of events that normally result[s] in tumor suppression. They published their results April 4 in Cancer Cell.

"When we started studying SIRT4, we were focused only on its metabolic role, looking for functions related to diabetes and obesity," said Haigis. "What we found, to our surprise, was that SIRT4 was responsive to DNA damage, so that led us to investigate the metabolic response to DNA damage and how SIRT4 controls the metabolic response to genotoxic stress."

To see how SIRT4 normally functions, Haigis and her colleagues induced DNA damage by exposing cells in a lab dish to ultraviolet light. This damage triggered a halt in glutamine metabolism, limiting the amount of nutrients the cell could use as it goes through a cycle of division and growth.

Blocking the cell cycle at this juncture is important. If cell growth after DNA damage goes unchecked, proliferation of impaired cells can lead to cancer. When SIRT4 works properly, this chain of events is broken before bad cells and their abnormal genes multiply. SIRT4 blocks glutamine metabolism, arrests the cell cycle and suppresses tumor formation.

The scientists tested this SIRT4 response in mice. Bred to lack the gene that encodes the SIRT4 protein but otherwise normal, the mice spontaneously developed lung cancer by 15 months.

"When SIRT4 is missing, you don't have this metabolic checkpoint involving glutamine, which is important because glutamine is an amino acid required for proliferation in the cell," Haigis said. "Without SIRT4, the cell keeps dividing even in the face of DNA damage, so the cell accumulates more damage."

The scientists also analyzed data showing SIRT4 gene expression levels are low in several human cancers, including small-cell lung carcinoma, gastric cancer, bladder carcinoma, breast cancer and leukemia.

While they cannot say if SIRT4 loss alone will initiate cancer, its absence appears to create an environment in which tumor cells survive and grow.

"Our findings suggest that SIRT4 may be a potential target against tumors," they conclude.

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The above story is reprinted from materials provided by Harvard Medical School. The original article was written by Elizabeth Cooney.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Seung?Min Jeong, Cuiying Xiao, Lydia?W.S. Finley, Tyler Lahusen, Amanda?L. Souza, Kerry Pierce, Ying-Hua Li, Xiaoxu Wang, Ga?lle Laurent, Natalie?J. German, Xiaoling Xu, Cuiling Li, Rui-Hong Wang, Jaewon Lee, Alfredo Csibi, Richard Cerione, John Blenis, Clary?B. Clish, Alec Kimmelman, Chu-Xia Deng, Marcia?C. Haigis. SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism. Cancer Cell, 2013; DOI: 10.1016/j.ccr.2013.02.024

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/g2hXsrHcg8E/130405094517.htm

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Ten Ways to Overcome Creativity's Number One Crusher

"The worst enemy of creativity is self-doubt," wrote Sylvia Plath in her journal. And she couldn't have been more accurate. Self-doubt can persuade us to stop creating or keep us from sending our work out into the world. It can be so influential that it colors how we see ourselves, ensuring we don't pick up a pen, paintbrush, camera, or other tool for decades.

"Self-doubt paralyzed me for 25 years," said Meghan Davidson, Ph.D, a psychologist, professor, and researcher at the University of Nebraska. When Davidson was eight years old, her art teacher wrote in her report card that she had "no artistic ability whatsoever." This destroyed Davidson. Her teacher's words became a running joke in her family, who had no idea of their crushing effect. It was only after a personal health crisis reminded her of the brevity of life that Davidson decided to pursue her creativity. She picked up a camera. Today, she's an accomplished photographer whose work has been featured in gallery shows and publications such as UPPERCASE and Artful Blogging.

Jolie Guillebeau's project of 100 paintings a day "originated entirely from self-doubt." "In February 2010, I wasn't sure that I could even call myself an artist, because I wasn't really painting. I'd been paralyzed from my own angst and hadn't picked up a paintbrush in months." She decided to prove herself wrong. After completing 100 paintings, Guillebeau felt more like an artist. But her self-doubt lingered. So she stepped out of the comfort of her studio, and painted outside for an entire summer.

Tips to Overcome Self-Doubt

"Creativity means navigating new terrain, and it's scary and uncomfortable," according to Carla Sonheim, an illustrator, workshop instructor, and author of the book The Art of Silliness: A Creativity Book for Everyone.

So feeling self-doubt is natural. "Self-doubt is a part of human nature," Davidson said. But because it sabotages creativity, it's important to know how to overcome it. Here are 10 ways to surmount self-doubt, so you can focus on the good stuff: creating.

Remember self-doubt is a story.
As Davidson said, thinking you're not good at something doesn't make it true. Her art teacher triggered her self-doubt, but it was the stories spinning in Davidson's mind that stopped her from creating. And these disempowering tales were clearly distorted.

Remember why you create.
"Remind yourself of what you want to do and why you want to do it," Davidson said. For instance, connecting to your creativity might be part of your self-care or a longing in your spirit, she said.

Take small steps.
Even when self-doubt is deafening, "take tiny steps toward your goal every day," Guillebeau said. "Maybe you can't create the Great American Novel today, but perhaps you can write 750 words? Or your self-doubt is in the way of creating a painting, but at least going to the art supply store and buying a paintbrush is possible."

Marvel at others' talent.
When painting alongside her artist friend, Gail McMeekin would feel a flood of self-doubt and insecurity. "[I'd] feel overshadowed and totally inept," said McMeekin, LICSW, a coach to creative women entrepreneurs and professionals and author of The 12 Secrets of Highly Creative Women. Today, instead of letting someone else's talents negate her own or hinder her creativity, she's learned to "adopt an attitude of wonderment."

She encouraged readers to "Notice the genius of the people who are teaching you or sharing a moment with you and soak up what you admire and aspire to, to use in your own work. Enjoy the privilege of being around creators who inspire you without trashing yourself."

Reframe your self-doubt.
Like Guillebeau did with her painting projects, use self-doubt to fuel your creativity. Prove it wrong. Take the challenge. "By determining to prove that naysayer wrong, I've managed to create a daily painting practice that has evolved in to my livelihood and my career," Guillebeau said.

Consider the positive side of self-doubt, like Sonheim. "Self-doubt often acts as a measuring stick, helping me to determine whether I'm playing it safe or really sticking my neck out."

Surround yourself with supportive people.
"Look for supportive or encouraging people to help cheer you on [in your creative pursuits]," Davidson said.

Celebrate your creations.
For instance, McMeekin displays her paintings around her home. "Let your work remind you that beauty can appear when you trust yourself and luxuriate in your fascinations and playfulness," she said.

Talk to someone you trust.
Even if they don't really understand what you are going on about, their comments and questions?and your gut reactions to them?can help clarify the why of your uneasiness," Sonheim said.

You'll also be able to process your emotions more effectively when you figure out if they're internal or external, she said.

Find what puts you in your creative zone.
"Experiment until you discover what puts you into your theta brain and sparks your creative journey," McMeekin said. She turns to journaling, music and other inspirational tools, such as her Creativity Courage Cards. "I often wear out the same music, and even one song over and over, at times, as the melody entrances me to create and get into my fertile garden in my mind."

Just go for it.
"You have nothing to lose," Davidson said. (You don't have to share your creations with anyone, she said.) "I wish I hadn't listened to the self-doubt gremlins for 20-some years. I could've been doing this for all this time. But it's never too late to just jump in and play. And go in with childlike curiosity." That childlike curiosity is a great reminder of how limitless, joyful and incredibly liberating creativity can be. "I often remember the utter joy I felt in kindergarten on that first day when I dipped my hands in gorgeous, brightly colored fingerpaints and was told that I could put my paints on my wet paper any way I chose and it would be all right," McMeekin said.

"Overcoming self-doubt involves believing that you can do it, accepting your strengths and limitations, fixing what you can, and then taking a risk by moving forward, even if you don't have all the answers," Sonheim said. She shared this quote from actor and author Alan Alda on creativity: "Be brave enough to live creatively. The creative is the place where no one else has been. You have to leave the city of your comfort and go into the wilderness of your intuition. You cannot get there by bus, only by hard work, risking and by not quite knowing what you are doing. What you will discover will be wonderful: Yourself."

10 Ways to Overcome Creativity's No. 1 Crusher?Psych Central

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Copyright (C) 2013 Psych Central. All rights reserved. Reprinted here with permission from http://psychcentral.com/blog/archives/2013/03/03/10-ways-to-overcome-creativitys-no-1-crusher/.

Margarita Tartakovsky is an associate editor at the psychology and mental health website Weightless, a blog that helps women love their bodies and themselves, at every shape and size. Learn more about Margarita at her website, where she shares slices from her life, posts her poetry, and writes about all things writing.

Want to see your work on Lifehacker? Email Tessa.

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Do Not Give A Lightsaber To A Baby

It seems like a simple enough concept, but it took this brave found footage video from Joel and Jared Erickson (via io9) to teach us the hard lesson that children should never, ever have access to lightsabers. The video was filmed with a few different camera phones and shows what happens when a toddler gets [...]

Source: http://moviesblog.mtv.com/2013/04/03/baby-lightsaber/

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Discovery of 1,800-year-old 'Rosetta Stone' for tropical ice cores

Apr. 4, 2013 ? Two annually dated ice cores drawn from the tropical Peruvian Andes reveal Earth's tropical climate history in unprecedented detail -- year by year, for nearly 1,800 years.

Researchers at The Ohio State University retrieved the cores from a Peruvian ice cap in 2003, and then noticed some startling similarities to other ice cores that they had retrieved from Tibet and the Himalayas. Patterns in the chemical composition of certain layers matched up, even though the cores were taken from opposite sides of the planet.

In the April 4, 2013 online edition of the journal Science Express, they describe the find, which they call the first annually resolved "Rosetta Stone" with which to compare other climate histories from Earth's tropical and subtropical regions over the last two millennia.

The cores provide a new tool for researchers to study Earth's past climate, and better understand the climate changes that are happening today.

"These ice cores provide the longest and highest-resolution tropical ice core record to date," said Lonnie Thompson, distinguished university professor of earth sciences at Ohio State and lead author of the study.

"In fact, having drilled ice cores throughout the tropics for more than 30 years, we now know that this is the highest-resolution tropical ice core record that is likely to be retrieved."

The new cores, drilled from Peru's Quelccaya Ice Cap, are special because most of their 1,800-year history exists as clearly defined layers of light and dark: light from the accumulated snow of the wet season, and dark from the accumulated dust of the dry season.

They are also special because of where they formed, atop the high Andean altiplano in southern Peru. Most of the moisture in the area comes from the east, in snowstorms fueled by moist air rising from the Amazon Basin. But the ice core-derived climate records from the Andes are also impacted from the west -- specifically by El Ni?o, a temporary change in climate, which is driven by sea surface temperatures in the tropical Pacific.

El Ni?o thus leaves its mark on the Quelccaya ice cap as a chemical signature (especially in oxygen isotopes) indicating sea surface temperatures in the equatorial Pacific Ocean over much of the past 1,800 years.

"We have been able to derive a proxy for sea surface temperatures that reaches back long before humans were able to make such measurements, and long before humans began to affect Earth's climate," Thompson said.

Ellen Mosley-Thompson, distinguished university professor of geography at Ohio State and director of the Byrd Polar Research Center, explained that the 2003 expedition to Quelccaya was the culmination of 20 years of work.

The Thompsons have drilled ice cores from glaciers atop the most remote areas of the planet -- the Chinese Himalayas, the Tibetan Plateau, Kilimanjaro in Africa, and Papua Indonesia among others -- to gauge Earth's past climate. Each new core has provided a piece of the puzzle, as the researchers measured the concentrations of key chemicals preserved in thousands of years of accumulated ice.

A 1983 trip to Quelccaya yielded cores that earned the research team their first series of papers in Science. The remoteness of the site and the technology available at the time limited the quality of samples they could obtain, however. The nearest road was a two-day walk from the ice cap, so they were forced to melt the cores in the field and carry samples back as bottles of water. This made some chemical measurements impossible, and diminished the time resolution available from the cores.

"Due to the remoteness of the ice cap, we had to develop new tools such as a light-weight drill powered by solar panels to collect the 1983 cores. However, we knew there was much more information the cores could provide" Mosley-Thompson said. "Now the ice cap is just a six-hour walk from a new access road where a freezer truck can be positioned to preserve the cores. So we can now make better dust measurements along with a suite of chemical analyses that we couldn't make before."

The cores will provide a permanent record for future use by climate scientists, Thompson added. This is very important, as plants captured by the advancing ice cap 6,000 years ago are now emerging along its retreating margins, which shows that Quelccaya is now smaller than it has been in six thousand years.

"The frozen history from this tropical ice cap -- which is melting away as Earth continues to warm -- is archived in freezers at -30?C so that creative people will have access to it 20 years from now, using instruments and techniques that don't even exist today," he said.

Coauthors on the study include Mary Davis, Victor Zagorodnov, and Ping-Nan Lin of Byrd Polar Research Center; Ian Howat of the School of Earth Sciences at Ohio State; and Vladimir Mikhalenko of the Russian Academy of Sciences. Funding was provided by the National Science Foundation's Paleoclimatology Program and Ohio State's Climate, Water and Carbon Program.

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The above story is reprinted from materials provided by Ohio State University, via Newswise.

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Journal Reference:

1. L. G. Thompson, E. Mosley-Thompson, M. E. Davis, V. S. Zagorodnov, I. M. Howat, V. N. Mikhalenko, and P.-N. Lin. Annually Resolved Ice Core Records of Tropical Climate Variability Over the Past ~1800 Years. Science, 4 April 2013 DOI: 10.1126/science.1234210

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Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/TwMXf_qzw9U/130404142417.htm

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Epileptic seizures can propagate using functional brain networks

Apr. 2, 2013 ? The seizures that affect people with temporal-lobe epilepsy usually start in a region of the brain called the hippocampus. But they are often able to involve other areas outside the temporal lobe, propagating via anatomically and functionally connected networks in the brain. New research findings that link decreased brain cell concentration to altered functional connectivity in temporal-lobe epilepsy are reported in an article in Brain Connectivity, a bimonthly peer-reviewed publication from Mary Ann Liebert, Inc., publishers.

Martha Holmes and colleagues from Vanderbilt University, Nashville, TN, identified regions in the brains of patients with temporal-lobe epilepsy that had reduced gray-matter concentrations. Greater reductions in gray-matter concentration correlated with either decreased or increased signaling and communication between brain regions connected through known functional networks.

The authors present their findings in the article "Functional Networks in Temporal-Lobe Epilepsy: A Voxel-Wise Study of Resting-State Functional Connectivity and Gray-Matter Concentration."

"This is one of the first studies to actually correlate both functional and structural brain changes in epilepsy," says Christopher Pawela, PhD, Co-Editor-in-Chief and Assistant Professor, Medical College of Wisconsin. "This is an exciting finding and may have impact in other brain disorders in which both the structure and function of the brain are involved."

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The above story is reprinted from materials provided by Mary Ann Liebert, Inc., Publishers.

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Journal Reference:

1. Martha J. Holmes, Xue Yang, Bennett A. Landman, Zhaohua Ding, Hakmook Kang, Bassel Abou-Khalil, Hasan H. Sonmezturk, John C. Gore, Victoria L. Morgan. Functional Networks in Temporal-Lobe Epilepsy: A Voxel-Wise Study of Resting-State Functional Connectivity and Gray-Matter Concentration. Brain Connectivity, 2013; 3 (1): 22 DOI: 10.1089/brain.2012.0103

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/izmTonxmUgg/130402144625.htm

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